Science
BERLIN: Scientists decode how coronavirus interacts with proteins in human cells
BERLIN:
Scientists have charted the first atlas showing how the genetic material of the
novel coronavirus interacts with the proteins in human cells, an advance which
may provide a starting point for the development of new treatments against
Covid-19.
According to the researchers, including those from Broad Institute in the US,
one of the most urgent tasks is to understand all the molecular interactions
between the virus and the cells it infects.
They explained that a detailed understanding of these interactions will help
identify the processes in host cells which favour the multiplication of the
virus, and the ones which activate the host immune system.
While the SARS-CoV-2 virus uses host proteins to replicate, the scientists said
until now, there has been no detailed understanding of all the proteins
occurring in human cells which interact with the viral genetic material — its
RNA.
In the current research, published in the journal Nature Microbiology, the
scientists created the first global atlas of direct interactions between the
SARS-CoV-2 RNA and the proteins present in human cells.
Based on the findings, the researchers also identified important regulators of
viral replication.
The scientists infected human cells with the novel coronavirus, purified the
viral RNA and identified the proteins bound to it.
“In this particular case, we were able to perform quantitative
measurements to identify the strongest specific binding partners,” said
study co-author Mathias Munschauer from the Helmholtz Institute for RNA-based
Infection Research (HIRI) in Germany.
The scientists said the atlas of RNA-protein interactions offers unique
insights into SARS-CoV-2 infections, enabling the systematic breakdown of
factors influencing the replication of the virus, and host defense strategies
— a crucial prerequisite for the development of new therapeutics.
From the results, the scientists identified 18 host proteins that play an
important role during SARS-CoV-2 infection, and found 20 small molecules that
may inhibit these proteins.
They believe the two proteins CNBP and LARP1 are particularly interesting.
The researchers also identified target sites in these proteins that could be
used to inhibit the replication of the virus.
According to Munschauer, the characterization of LARP1 as an antiviral factor
is a major finding.
“The way LARP1 binds to viral RNA is very interesting, because it is
similar to the way LARP1 regulates certain cellular messenger RNAs that we
already know. This in turn provides insights into possible mechanisms of
action,” he added.
According to the scientists, three out of four small molecules they tested
inhibited viral replication in different human cell types — findings that may
open up new ways to treat Covid-19.
Science
SAN FRANCISCO: Indian-Origin Founder Unveils Wearable Device That Records Every Moment Of Your Life
SAN FRANCISCO: Advait Paliwal, an Indian-origin entrepreneur, has recently introduced a wearable AI device called Iris, designed to provide users with “infinite memory.” According to Paliwal, the device captures “pictures every minute,” which are stored either on the device or in the cloud, allowing users to preserve life’s small moments and recognize patterns often overlooked.
In a series of tweets, Mr Paliwal, who is based in San Francisco, explained that Iris not only organises the photos into a timeline but also uses AI to generate captions and help users recall forgotten details. Additionally, the device features a “focus mode,” which detects when the wearer is distracted and offers reminders to refocus.
Mr. Paliwal shared that the design of Iris is inspired by the evil eye symbol. He developed the device over the summer at the Augmentation Lab in Cambridge, part of a two-month AI and hardware talent accelerator program. After the program, Mr Paliwal presented Iris to over 250 attendees at the MIT Media Lab, where he received positive feedback, with many expressing interest in owning the device.
Highlighting its potential, Mr Paliwal suggested that Iris could offer safety and health benefits, such as aiding doctors in understanding patients’ daily habits or ensuring workplace safety compliance. In elderly care, the device could help caregivers monitor patients without being intrusive.
However, after Mr Paliwal shared his post on X (formerly Twitter), reactions were mixed. While some users expressed excitement, others raised privacy concerns. One person commented, “It’s an interesting concept, but I wouldn’t want to interact with someone wearing this, taking a photo every minute.” Paliwal responded by pointing out that people are already “constantly taking mental photos.”
Others were more enthusiastic, with one user noting, “I’ve been searching for a device like this for years! A picture every minute should be enough if it archives, organizes, labels, and retrieves them.” Another user praised the concept, saying, “Love the idea. The design and name are perfect. Great work!”
Science
TEXAS: Meet Gopi Thotakura, Indian Who Will Soon Go To The Edge Of Outer Space
TEXAS: In an unprecedented leap towards the stars, pilot Gopichand Thotakura is set to become the first Indian to venture into space as a tourist. Selected as part of the elite crew for Blue Origin’s New Shephard-25 (NS-25) mission, Mr Thotakura will make a journey beyond the Earth’s atmosphere along with five other candidates.
Gopichand Thotakura, an entrepreneur and pilot, joins a distinguished lineup of 31 candidates who have flown beyond the Karman line, the boundary between Earth’s atmosphere and outer space.
A connoisseur of the skies since his youth, Mr Thotakura’s passion for flight saw him defy conventional norms, learning to pilot aircraft before mastering the art of driving. To further his passion, he graduated from Embry-Riddle Aeronautical University with a Bachelor of Science in Aeronautical Science.
Describing him, Blue Origins wrote, “Gopi is a pilot and aviator who learned how to fly before he could drive. Gopi pilots bush, aerobatic, and seaplanes, as well as gliders and hot air balloons, and has served as an international medical jet pilot. A lifelong traveler, his most recent adventure took him to the summit of Mt. Kilimanjaro.”
Born in Vijayawada, the 30-year-old currently runs Preserve Life Corp, a global center for holistic wellness and applied health located near Hartsfield-Jackson Atlanta International Airport
Each member of the NS-25 mission will carry a postcard on behalf of Blue Origin’s foundation, Club for the Future, symbolizing the collective dreams and aspirations of young minds worldwide.
From an environmental standpoint, the NS-25 mission heralds a new era of sustainability in space exploration.
“Nearly 99% of New Shepard’s dry mass is reused, including the booster, capsule, engine, landing gear, and parachutes. New Shepard’s engine is fueled by highly efficient liquid oxygen and hydrogen. During flight, the only byproduct is water vapor with no carbon emissions,” Blue Origins said in their statement.
The launch date for the mission is yet to be announced.
The mission also includes former Air Force Captain Ed Dwight, who was selected by US President John F Kennedy in 1961 as the country’s first Black astronaut candidate but was never granted the opportunity to fly to space.
Blue Origin has carried out six crewed flights — some passengers were paying customers and others were guests — since July 2021, when CEO Jeff Bezos himself took part in the first.
The company is also developing a heavy rocket for commercial purposes called New Glenn, with the maiden flight planned for next year.
This rocket, which measures 98 meters (320 feet) high, is designed to carry payloads of as much as 45 metric tons into low Earth orbit.
Science
WASHINGTON: Who Is Aroh Barjatya, Indian-Origin Researcher Who Led Recent NASA Mission
WASHINGTON: Aroh Barjatya, an India-born researcher, led NASA’s mission that launched sounding rockets during the recent total solar eclipse.
The US space agency launched three sounding rockets during the total solar eclipse on April 8 to study what happens to the Earth’s upper atmosphere when sunlight dims momentarily over a part of the planet.
Who Is Aroh Barjatya?
A professor of engineering physics, Aroh Barjatya directs the Space and Atmospheric Instrumentation Lab at the Embry-Riddle Aeronautical University in Florida.
Born to a chemical engineer, Ashok Kumar Barjatya, and his wife Rajeshwari, Aroh Barjatya went to schools across India, including in Patalganga near Mumbai, Hyderabad, Jaipur, Pilani, and Solapur.
He went on to get a degree in electronics engineering from Solapur’s Walchand Institute of Technology.
In 2021, he moved to the US for a master’s degree in electrical engineering at Utah State University. He later did his PhD in spacecraft instrumentation from the same university.
“In addition to leading an externally funded research enterprise, as a tenured faculty I have mentored and engaged young minds through inquiry-based learning tactics, created a new area of concentration within the Engineering Physics programme at ERAU… My mission is to advance the state of the art in space research and education and to inspire the next generation of space engineers and scientists,” he wrote on his LinkedIn profile.
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